HLA Polymorphism in Anthropology
نویسندگان
چکیده
Humans are the most adaptable species among living organisms. Adaptation is the sum of all processes which allows the organism to cope with environmental stresses, in particular climate and topography, for its survival. All living species continuing through time and space to the present day are endowed with innate biological adaptation. The whole gamut of biological adaptation of human species is dependent on the sum total of anatomical, physiological, immunological and genetic characteristics. But the human species, in addition to biological adaptation, also possess cultural adaptation. Cultures are customs and traditions which help shape the human body and mind. The quest for understanding diversity of his own species and the rest of the species through time and space has promoted the expansion of the science of biological/physical Anthropology [1].
منابع مشابه
Iranian Lurs Genetic Diversity: An Anthropological View Based on HLA Class II Profiles
Background: HLA genes are highly polymorphic and certain alleles are frequent only in specific populations. Therefore, HLA is a unique tool for studying the genetic relationship between different populations. Iranians are ethnically diverse people and one of the major ethnic groups in Iran is Lur population inhabiting along the central and southern parts of Zagros Chain Mountain. Objectives: Ge...
متن کاملRole of HLA-G 14 bp Indel polymorphism on susceptibility to HTLV-1 infection in blood donors of Khorasan Razavi Blood Center
Abstract Background and Objectives The HLA-G antigen is a non-classical HLA class-I with limited polymorphism. Several studies have indicated the role of a 14 bp Indel polymorphism rs371194629 in the 3'-UTR region of the HLA-G in acquisition of HTLV-1 infection. In this study, we investigated the correlation between the genotypes of this polymorphism and HTLV-1 infection in blood donors of Khor...
متن کاملP-203: Investigating Association of HLA-G Gene Polymorphisms and Failed Implantation in Human Embryos
Background: HLA-G is a non-classical human leukocyte antigen expressed primarily in fetal tissues at the maternal-fetal interface. The unique structure of HLA-G molecule permits a restricted peptide presentation and allows the modulation of the immune system. There is now general agreement that HLA-G is an important immunotolerant molecule with the capability of inhibiting immune cell functions...
متن کاملSignificant Associations of the rs3104413 Single-nucleotide Polymorphism in the HLA Region with Type 1 Diabetes
Background and Aims: In this study, the effect of rs310441 polymorphism in the human leukocyte antigen (HLA) region on the development of susceptibility or resistance to Type 1 diabetes (T1D) among the people with T1D compared to healthy subjects has been investigated. Materials and Methods: This research, which is based on the examination of 130 cases with T1D and 98 controls, has been carrie...
متن کاملHLA Class I Gene Polymorphism in Iranian Patients with Papillon-Lefevre Syndrome
Background: Papillon-Lefevre Syndrome (PLS) is a rare autosomal recessive disorder characterized by diffused palmoplantar keratoderma and severe periodontitis. Increased susceptibility to infections due to impairment of the immune system is considered to be involved in pathoetiology of this disease. Objective: According to the crucial function of HLA molecules in immune responses and associati...
متن کامل